Cytotoxic halogenated metabolites from the Brazilian red alga Laurencia catarinensis

J Nat Prod. 2010 Jan;73(1):27-32. doi: 10.1021/np900627r.

Cintia Lhullier ¹, Miriam Falkenberg, Efstathia Ioannou, Antonio Quesada, Panagiota Papazafiri, Paulo Antunes Horta, Eloir Paulo Schenkel, Constantinos Vagias, Vassilios Roussis

Affiliations

Affiliation

1 Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.

PMID: 20039643 DOI: 10.1021/np900627r

Abstract

Seven new (1-7) and seven previously reported (8-14) halogenated metabolites were isolated from the organic extract of the Brazilian red alga Laurencia catarinensis. The structure elucidation and the assignment of the relative configurations of the new Natural Products were based on detailed NMR and MS spectroscopic analyses, whereas the structure of metabolite 6 was confirmed by single-crystal X-ray diffraction analysis. The absolute configuration of metabolite 1 was determined using the modified Mosher's method. The in vitro cytotoxicity of compounds 1-14 was evaluated against HT29, MCF7, and A431 cell lines.

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