2. Academic Validation
  3. Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents

  • Bioorg Med Chem Lett. 2010 Feb 1;20(3):1040-4. doi: 10.1016/j.bmcl.2009.12.045.
Sumesh Eswaran 1,  Airody Vasudeva Adhikari,  Nishith K Pal,  Imran H Chowdhury
Affiliations

Affiliation

  • 1 Anthem Biosciences Pvt Ltd, 49 Bommasandra Industrial Area, Bommasandra, Bangalore 560 099, Karnataka, India.
PMID: 20056418 DOI: 10.1016/j.bmcl.2009.12.045
Abstract

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC(2)), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis.

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