2. Academic Validation
  3. Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates

Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates

  • Antimicrob Agents Chemother. 2010 Mar;54(3):1338-42. doi: 10.1128/AAC.01197-09.
Tsai-Ling Lauderdale 1,  Yih-Ru Shiau,  Jui-Fen Lai,  Hua-Chien Chen,  Chi-Hsin R King
Affiliations

Affiliation

  • 1 Division of Infectious Diseases, National Health Research Institutes, 35 Keyan Rd. Zhunan, Taiwan 350. lauderdale@nhri.org.tw
PMID: 20065058 DOI: 10.1128/AAC.01197-09
Abstract

The in vitro Antibacterial activities of nemonoxacin (TG-873870), a novel nonfluorinated Quinolone, against 770 clinical isolates were investigated. Nemonoxacin (tested as its malate salt, TG-875649) showed better in vitro activity than ciprofloxacin and levofloxacin against different species of staphylococci, streptococci, and enterococci, Neisseria gonorrhoeae, and Haemophilus influenzae. The in vitro activity of TG-875649 was also comparable to or better than that of moxifloxacin against these pathogens, which included ciprofloxacin-resistant, methicillin-resistant Staphylococcus aureus and levofloxacin-resistant Streptococcus pneumoniae.

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