2. Academic Validation
  3. Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity

Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity

  • Bioorg Med Chem Lett. 2010 Mar 15;20(6):1961-4. doi: 10.1016/j.bmcl.2010.01.122.
Hai Ling Sun 1,  Tian Tian Wang,  Zhi Liang Lv,  Ji Lu Feng,  Dong Ping Geng,  Yong Mei Li,  Ke Li
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
PMID: 20171096 DOI: 10.1016/j.bmcl.2010.01.122
Abstract

A kind of racemic furan Lignans were synthesized via a novel route, and two optical isomers were obtained through a selective hydrolization. The absolute configurations were determined by circular dichroism spectroscopy after separated through a preparative column. The different activities of isomers and the racemates were evaluated on QGY-7701 and HeLa cell lines, and compound 2c showed the best activity on QGY-7701 and HeLa cell lines with IC(50) 12 microM and 13 microM, respectively.

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