2. Academic Validation
  3. Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams

Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams

  • Eur J Med Chem. 2010 Jun;45(6):2229-36. doi: 10.1016/j.ejmech.2010.01.064.
Neelima Dhingra 1,  T R Bhardwaj,  Neeraj Mehta,  Tapas Mukhopadhyay,  Ashok Kumar,  Manoj Kumar
Affiliations

Affiliation

  • 1 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
PMID: 20171759 DOI: 10.1016/j.ejmech.2010.01.064
Abstract

The 17-oxo-17a-aza-d-homo-5-androsten-3beta-yl esters (13-22) were synthesized from commercially available (25R)-5-spirosten-3beta-ol (Diosgenin) (6) as starting material. The synthesized compounds were evaluated for their antiproliferative activity, acute toxicity and effect on serum androgen level and were compared with Finasteride as positive controls. Some of the compounds exhibited better cytotoxicity and antiandrogenic activity than the reference control. The detailed synthesis, spectroscopic data and pharmacological screening for the synthesized compounds were reported.

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