2. Academic Validation
  3. Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives

  • Eur J Med Chem. 2010 Jun;45(6):2299-306. doi: 10.1016/j.ejmech.2010.02.005.
Min Sun 1,  Xiaoqing Wu,  Junqing Chen,  Jin Cai,  Meng Cao,  Min Ji
Affiliations

Affiliation

  • 1 Pharmaceutical Engineering Institute, School of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096, PR China.
PMID: 20181414 DOI: 10.1016/j.ejmech.2010.02.005
Abstract

Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung Cancer (NSCLC) cell line A549 and human breast Cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.

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