2. Academic Validation
  3. 2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent

  • Bioorg Med Chem Lett. 2010 Apr 1;20(7):2275-8. doi: 10.1016/j.bmcl.2010.02.007.
Tadashi Honda 1,  Eric M Padegimas,  Emilie David,  Chitra Sundararajan,  Karen T Liby,  Charlotte Williams,  Michael B Sporn,  Melean Visnick
Affiliations

Affiliation

  • 1 Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA. th9@dartmouth.edu
PMID: 20188548 DOI: 10.1016/j.bmcl.2010.02.007
Abstract

2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride (CDDO anhydride) has been synthesized, which is the first example of an oleanane triterpenoid anhydride. CDDO anhydride shows potency similar to or higher than the corresponding acid (CDDO) in various in vitro and in vivo assays related to inflammation and carcinogenesis. Notably, preliminary phamacokinetics studies show that CDDO anhydride levels are higher than CDDO levels in mouse tissues and blood. Further evaluation of CDDO anhydride is in progress.

Figures