2. Academic Validation
  3. Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones

Synthesis, anticancer and antioxidant activities of 7-methoxyisoflavanone and 2,3-diarylchromanones

  • Eur J Med Chem. 2010 Jun;45(6):2447-52. doi: 10.1016/j.ejmech.2010.02.028.
Kanagasabai Kanagalakshmi 1,  Mariappan Premanathan,  Ragunathan Priyanka,  Balasubramanian Hemalatha,  Arumugasamy Vanangamudi
Affiliations

Affiliation

  • 1 Centre for Research and Post-graduate studies in Chemistry, Ayya Nadar Janaki Ammal College, Sivakasi 626 124, Tamil Nadu, India.
PMID: 20227144 DOI: 10.1016/j.ejmech.2010.02.028
Abstract

A convenient, fast and high yielding method for the preparation of 7-methoxyisoflavanone and 2,3-diarylchromanones has been developed by the condensation of benzyl-2-hydroxy-4-alkoxyphenylketone with arylaldehyde/paraformaldehyde in presence of diethylamine, assisted by microwave activation. All the synthesized compounds were screened for Anticancer as well as antioxidant activities. Among the nine compounds, 7-methoxyisoflavanone 7 and diarylchromanone 6c shows potential Anticancer activity and diarylchromanone 6b has potential antioxidant activity. Compound 6h possesses Anticancer and antioxidant activity at the same concentration.

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