2. Academic Validation
  3. (-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu)

  • Bioorg Med Chem Lett. 2010 Apr 15;20(8):2601-4. doi: 10.1016/j.bmcl.2010.02.074.
Jagadeeshwar R Rao 1,  Ashok K Jha,  Ravindra K Rawal,  Ashoke Sharon,  Craig W Day,  Dale L Barnard,  Donald F Smee,  Chung K Chu
Affiliations

Affiliation

  • 1 The University of Georgia College of Pharmacy, Athens, GA 30602, USA.
PMID: 20231094 DOI: 10.1016/j.bmcl.2010.02.074
Abstract

Enantiomerically pure cyclopentyl cytosine [(-)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (+/-)-carbodine and ribavirin. (-)-Carbodine 1 exhibited potent Antiviral activity against various strains of influenza A and B viruses.

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