2. Academic Validation
  3. New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents

New 3-methylquinoxaline-2-carboxamide 1,4-di-N-oxide derivatives as anti-Mycobacterium tuberculosis agents

  • Bioorg Med Chem. 2010 Apr 1;18(7):2713-9. doi: 10.1016/j.bmc.2010.02.024.
Saioa Ancizu 1,  Elsa Moreno,  Beatriz Solano,  Raquel Villar,  Asunción Burguete,  Enrique Torres,  Silvia Pérez-Silanes,  Ignacio Aldana,  Antonio Monge
Affiliations

Affiliation

  • 1 Unidad de Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), University of Navarra, C/Irunlarrea s/n, 31008 Pamplona, Spain.
PMID: 20233660 DOI: 10.1016/j.bmc.2010.02.024
Abstract

Mycobacterium tuberculosis (M.Tb) is a bacillus capable of causing a chronic and fatal condition in humans known as tuberculosis (TB). It is estimated that there are 8 million new cases of TB per year and 3.1 million infected people die annually. Thirty-six new amide quinoxaline 1,4-di-N-oxide derivatives have been synthesized and evaluated as potential anti-tubercular agents, obtaining biological values similar to the reference compound, Rifampin (RIF).

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