2. Academic Validation
  3. Bioactive metabolites from cultures of basidiomycete Favolaschia tonkinensis

Bioactive metabolites from cultures of basidiomycete Favolaschia tonkinensis

  • J Nat Prod. 2010 Apr 23;73(4):759-62. doi: 10.1021/np900777r.
Jittra Kornsakulkarn 1,  Chawanee Thongpanchang,  Rittikorn Chainoy,  Wilunda Choowong,  Sutichai Nithithanasilp,  Tienthong Thongpanchang
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, 113 Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
PMID: 20329738 DOI: 10.1021/np900777r
Abstract

Two strobilurins, 9-methoxystrobilurin B (1) and 9-methoxystrobilurin G (2), two monochlorinated 2,3-dihydro-1-benzoxepin derivatives, 3 and 4a, and butenolide 5, together with four known compounds, strobilurin B, 9-methoxystrobilurin A, and oudemansins A and B, were isolated from culture BCC 18689 of the fungus Favolaschia tonkinensis. 9-Methoxystrobilurins A, B (1), and G (2) and oudemansins A and B exhibited antimalarial, Antifungal, and cytotoxic activities, while compounds 3, 4a, and 5 displayed only cytotoxic activity.

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