2. Academic Validation
  3. cis-Clerodane-type furanoditerpenoids from Tinospora crispa

cis-Clerodane-type furanoditerpenoids from Tinospora crispa

  • J Nat Prod. 2010 Apr 23;73(4):541-7. doi: 10.1021/np900551u.
M Iqbal Choudhary 1,  Muhammad Ismail,  Khozirah Shaari,  Ahmed Abbaskhan,  Samina A Sattar,  Nordin H Lajis,  Atta-ur-Rahman
Affiliations

Affiliation

  • 1 H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
PMID: 20356064 DOI: 10.1021/np900551u
Abstract

Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, borapetoside A (13), were revised on the basis of HMQC and HMBC correlations. No discernible activity was observed when compounds 10-13 were subjected to evaluation in cytotoxicity assays against human prostate Cancer (PC-3) and the normal mouse fibroblast (3T3) cell lines.

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