2. Academic Validation
  3. Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

Design and preparation of aza-analogues of benzo[c]phenanthridine framework with cytotoxic and antiplasmodial activities

  • Eur J Med Chem. 2010 Jul;45(7):2854-9. doi: 10.1016/j.ejmech.2010.03.006.
Ange-Désiré Yapi 1,  Nicolas Desbois,  Jean-Michel Chezal,  Olivier Chavignon,  Jean-Claude Teulade,  Alexis Valentin,  Yves Blache
Affiliations

Affiliation

  • 1 Laboratoire de chimie organique et thérapeutique, EA 3660 Unité de Molécules d'Intérêt Biologique, Faculté de Pharmacie, 7 boulevard Jeanne d'Arc, BP 89700, 21079 Dijon, France.
PMID: 20362359 DOI: 10.1016/j.ejmech.2010.03.006
Abstract

Benzo[c]phenanthridine Alkaloids represent interesting lead for the discovery of new potential antiplasmodial and/or Anticancer drugs. In this field, a novel library of aza-analogs of benzo[c]phenanthroline framework derivatives was designed and prepared. Although these compounds did not have specific antiplasmodial activities, some of them displayed specific in vitro activity against two Cancer lines especially compound 24 with an IC(50) against the MCF7 line of 0.6 microM.

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