2. Academic Validation
  3. Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes

Synthesis and cytotoxic activity of fluorinated analogues of Goniothalamus lactones. Impact of fluorine on oxidative processes

  • Eur J Med Chem. 2010 Jul;45(7):3213-8. doi: 10.1016/j.ejmech.2010.03.032.
Lidia Dumitrescu 1,  Doan Thi Mai Huong,  Nguyen Van Hung,  Benoit Crousse,  Danièle Bonnet-Delpon
Affiliations

Affiliation

  • 1 UMR-CNRS 8076, Molécules fluorées et chimie médicinale, IFR 141, Faculté de Pharmacie, Université Paris-Sud, J. B. Clément, 5, rue Jean-Baptiste Clement, 92290 Châtenay-Malabry, France.
PMID: 20392543 DOI: 10.1016/j.ejmech.2010.03.032
Abstract

Novel fluorinated analogues of goniothalamin 1 and howiinol A 2 have been prepared from trifluorocrotonate derivatives. Trifluoromethyl goniothalamin (R/S) 4 showed a slightly lower activity than 1, while the trifluoromethyl howiinol A 16 exhibited similar activities on several cell lines in the micromolar range. Unlike (R) goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems.

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