2. Academic Validation
  3. Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolines as antileishmanial agents

Synthesis of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carbolines as antileishmanial agents

  • Eur J Med Chem. 2010 Aug;45(8):3274-80. doi: 10.1016/j.ejmech.2010.04.004.
Ravi Kumar 1,  Shahnawaz Khan,  Aditya Verma,  Saumya Srivastava,  Preeti Viswakarma,  Suman Gupta,  Sanjeev Meena,  Neetu Singh,  Jayanta Sarkar,  Prem M S Chauhan
Affiliations

Affiliation

  • 1 Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow, India.
PMID: 20457476 DOI: 10.1016/j.ejmech.2010.04.004
Abstract

A series of 2-(pyrimidin-2-yl)-1-phenyl-2,3,4,9-tetrahydro-1H-beta-carboline derivatives has been synthesized and evaluated for antileishmanial activity against Leishmania donovani. Compound 8 exhibited best antileishmanial activity with IC(50) value of 1.93 microg/ml against amastigotes, high selectivity index, and was more active than reference drugs sodium stilbogluconate and pentamidine.

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