2. Academic Validation
  3. Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice

  • Fitoterapia. 2010 Oct;81(7):855-8. doi: 10.1016/j.fitote.2010.05.009.
M R Sulaiman 1,  E K Perimal,  M N Akhtar,  A S Mohamad,  M H Khalid,  N A Tasrip,  F Mokhtar,  Z A Zakaria,  N H Lajis,  D A Israf
Affiliations

Affiliation

  • 1 Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia.
PMID: 20546845 DOI: 10.1016/j.fitote.2010.05.009
Abstract

The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test.

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