2. Academic Validation
  3. 7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata

7',8'-Dihydroobolactone, a typanocidal alpha-pyrone from the rainforest tree Cryptocarya obovata

  • Bioorg Med Chem Lett. 2010 Jul 15;20(14):4057-9. doi: 10.1016/j.bmcl.2010.05.091.
Rohan A Davis 1,  Ozlem Demirkiran,  Melissa L Sykes,  Vicky M Avery,  Lekha Suraweera,  Gregory A Fechner,  Ronald J Quinn
Affiliations

Affiliation

  • 1 Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia.
PMID: 20558060 DOI: 10.1016/j.bmcl.2010.05.091
Abstract

Mass-directed isolation of the CH(2)Cl(2)/MeOH extract from the leaves of Cryptocarya obovata resulted in the purification of a new trypanocidal alpha-pyrone, 7',8'-dihydroobolactone (1). The chemical structure of 1 was determined by 1D/2D NMR, MS and CD data analysis. 7',8'-Dihydroobolactone was shown to inhibit Trypanosoma brucei brucei with an IC(50) of 2.8 microM.

Figures