2. Academic Validation
  3. Discovery of novel sphingosine kinase-1 inhibitors. Part 2

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

  • Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4. doi: 10.1016/j.bmcl.2010.06.019.
Yibin Xiang 1,  Bradford Hirth,  John L Kane Jr,  Junkai Liao,  Kevin D Noson,  Christopher Yee,  Gary Asmussen,  Maria Fitzgerald,  Christine Klaus,  Michael Booker
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Drug and Biomaterial R&D, Genzyme Corporation, Waltham, MA 02451, USA. yibin.xiang@genzyme.com
PMID: 20598880 DOI: 10.1016/j.bmcl.2010.06.019
Abstract

Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a rat PK study.

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