2. Academic Validation
  3. Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

Ganoderic acid Df, a new triterpenoid with aldose reductase inhibitory activity from the fruiting body of Ganoderma lucidum

  • Fitoterapia. 2010 Dec;81(8):1033-6. doi: 10.1016/j.fitote.2010.06.025.
Sri Fatmawati 1,  Kuniyoshi Shimizu,  Ryuichiro Kondo
Affiliations

Affiliation

  • 1 Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan, 812-8581, Japan.
PMID: 20603199 DOI: 10.1016/j.fitote.2010.06.025
Abstract

Ganoderic acid Df, a new lanostane-type triterpenoid, was isolated from the fruiting body of Ganoderma lucidum. Its structure was characterized as 7β, 11β-dihydroxy-3, 15, 23-trioxo-5α-lanosta-8-en-26-oic acid by 1D- and 2D-NMR spectra. This compound exhibited potent human Aldose Reductase inhibitory activity, with an IC(50) of 22.8 μM in vitro. A carboxyl group of this compound's side chain is essential for eliciting inhibitory activity because its methyl ester is much less active.

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