2. Academic Validation
  3. Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation

Prenylflavonoids and prenyl/alkyl-phloroacetophenones: synthesis and antitumour biological evaluation

  • Eur J Med Chem. 2010 Sep;45(9):4258-69. doi: 10.1016/j.ejmech.2010.06.025.
P Basabe 1,  M de Román,  I S Marcos,  D Diez,  A Blanco,  O Bodero,  F Mollinedo,  B G Sierra,  J G Urones
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain. pbb@usal.es
PMID: 20619940 DOI: 10.1016/j.ejmech.2010.06.025
Abstract

Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active.

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