2. Academic Validation
  3. Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4

Regioselective hydrostannation of diarylalkynes directed by a labile ortho bromine atom: an easy access to stereodefined triarylolefins, hybrids of combretastatin A-4 and isocombretastatin A-4

  • Eur J Med Chem. 2010 Sep;45(9):3617-26. doi: 10.1016/j.ejmech.2010.05.007.
Evelia Rasolofonjatovo 1,  Olivier Provot,  Abdallah Hamze,  Jérome Bignon,  Sylviane Thoret,  Jean-Daniel Brion,  Mouâd Alami
Affiliations

Affiliation

  • 1 University Paris-Sud, CNRS, BioCIS-UMR 8076, Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, 5 rue J.-B. Clément, Châtenay-Malabry, F-92296, France.
PMID: 20627378 DOI: 10.1016/j.ejmech.2010.05.007
Abstract

A series of triarylolefins bearing the combretastatin A-4 and the isocombretastatin A-4 cores were synthesized and evaluated. The cooperative ortho-effect of a labile bromine atom in the regioselective hydrostannation of unsymmetrical diarylalkynes leading to stereodefined triarylolefins is presented.

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