2. Academic Validation
  3. Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

Synthesis and T-type calcium channel blocking activity of novel diphenylpiperazine compounds, and evaluation of in vivo analgesic activity

  • Bioorg Med Chem. 2010 Aug 15;18(16):5938-44. doi: 10.1016/j.bmc.2010.06.082.
Yoo Lim Kam 1,  Hee-Kyung Rhee,  Hyewhon Rhim,  Seung Keun Back,  Heung Sik Na,  Hea-Young Park Choo
Affiliations

Affiliation

  • 1 School of Pharmacy, Ewha Womans University, Seoul 120-750, Republic of Korea.
PMID: 20659804 DOI: 10.1016/j.bmc.2010.06.082
Abstract

Novel diphenylpiperazine derivatives were synthesized and evaluated for their inhibitory activity against T-type calcium channel by whole-cell patch clamp recordings on HEK293 cells. Among the test compounds, 2 and 3d were effective in decreasing the response to formalin in both the first and second phases and demonstrated antiallodynic effects in a rat model of neuropathic pain.

Figures