2. Academic Validation
  3. Tirucallane-type alkaloids from the bark of Dysoxylum laxiracemosum

Tirucallane-type alkaloids from the bark of Dysoxylum laxiracemosum

  • J Nat Prod. 2010 Aug 27;73(8):1385-8. doi: 10.1021/np100307f.
Xiang-Yun Zhang 1,  Yan Li,  Yuan-Yuan Wang,  Xiang-Hai Cai,  Tao Feng,  Xiao-Dong Luo
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
PMID: 20669932 DOI: 10.1021/np100307f
Abstract

Eight novel tirucallane-type Alkaloids (1-8) and 11 known compounds were isolated from a methanol extract of the bark of Dysoxylum laxiracemosum. The structures of 1-8 were elucidated using extensive NMR spectrometric and mass spectroscopic methods. Compounds 1 and 5, named laxiracemosins A and E, showed significant cytotoxicity against five human Cancer cell lines.

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