2. Academic Validation
  3. Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

Synthesis and biological evaluation of anilino substituted pyrimidine linked pyrrolobenzodiazepines as potential anticancer agents

  • Bioorg Med Chem Lett. 2010 Sep 1;20(17):5232-6. doi: 10.1016/j.bmcl.2010.06.147.
Ahmed Kamal 1,  J Surendranadha Reddy,  M Janaki Ramaiah,  E Vijaya Bharathi,  D Dastagiri,  M Kashi Reddy,  S N C V L Pushpavalli,  Manika Pal-Bhadra
Affiliations

Affiliation

  • 1 Division of Organic Chemistry, Indian Institute of Chemical Technology, Tarnaka, Hyderabad, India. ahmedkamal@iict.res.in
PMID: 20673627 DOI: 10.1016/j.bmcl.2010.06.147
Abstract

A series of new anilino substituted pyrimidine linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates were prepared and evaluated for their Anticancer activity. The effects of four promising PBD conjugates on cell cycle of cancerous cell line A375 were investigated. These compounds showed the characteristic features of Apoptosis like enhancement in the levels of p53, release of cytochrome c, and cleavage of PARP.

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