2. Academic Validation
  3. InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives

InCl3 mediated one-pot multicomponent synthesis, anti-microbial, antioxidant and anticancer evaluation of 3-pyranyl indole derivatives

  • Bioorg Med Chem Lett. 2010 Sep 1;20(17):5054-61. doi: 10.1016/j.bmcl.2010.07.039.
Neelakandan Vidhya Lakshmi 1,  Prakasam Thirumurugan,  K M Noorulla,  Paramasivan T Perumal
Affiliations

Affiliation

  • 1 Organic Chemistry Division, Central Leather Research Institute, Adyar, Chennai, Tamil Nadu, India.
PMID: 20675130 DOI: 10.1016/j.bmcl.2010.07.039
Abstract

A simple and convenient method for the one-pot three-component synthesis of 3-pyranyl indoles has been accomplished by tandem Knoevenagel-Michael reaction of 3-cyanoacetyl indole, various aromatic aldehydes and malononitrile catalyzed by InCl(3) in ethanol under reflux conditions. The newly synthesized 3-pyranyl indoles were evaluated for anti-microbial, antioxidant, and Anticancer activities. Some of the compounds showed good Anticancer activity against MCF-7 breast Cancer cell lines on comparison with of standard drug.

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