2. Academic Validation
  3. Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines

Design, synthesis, and anticancer activities of novel perfluoroalkyltriazole-appended 2'-deoxyuridines

  • Bioorg Med Chem Lett. 2010 Oct 1;20(19):5831-4. doi: 10.1016/j.bmcl.2010.07.126.
Sun Min Park 1,  Heeju Yang,  Song-Kyu Park,  Hwan Mook Kim,  Byeang Hyean Kim
Affiliations

Affiliation

  • 1 Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Republic of Korea.
PMID: 20732810 DOI: 10.1016/j.bmcl.2010.07.126
Abstract

We have focused on the C5-modification of 2'-deoxyuridine with substituted heterocycles for bioactivity, such as Antiviral or Anticancer activity. Herein, we report a novel class of nucleoside analogues with perfluoroalkyltriazole moiety as an Anticancer drug candidate.

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