2. Academic Validation
  3. Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line

Synthesis and cytotoxicity of some biurets against human breast cancer T47D cell line

  • Bioorg Med Chem Lett. 2010 Oct 1;20(19):5772-5. doi: 10.1016/j.bmcl.2010.07.137.
Shamileh Fouladdel 1,  Ali Khalaj,  Neda Adibpour,  Ebrahim Azizi
Affiliations

Affiliation

  • 1 Molecular Research Lab, Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
PMID: 20800481 DOI: 10.1016/j.bmcl.2010.07.137
Abstract

Design, synthesis and cytotoxicity of several known and novel biurets against human breast Cancer T47D cell line in comparison to doxorubicin are described. Biurets incorporating 2-methyl quinoline-4-yl and benzo[d]thiazol-2-ylthio moieties showed higher cytotoxicity and decreased cell viability in a concentration- and time-dependent manner.

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