2. Academic Validation
  3. FBI-1 functions as a novel AR co-repressor in prostate cancer cells

FBI-1 functions as a novel AR co-repressor in prostate cancer cells

  • Cell Mol Life Sci. 2011 Mar;68(6):1091-103. doi: 10.1007/s00018-010-0511-7.
Jiajun Cui 1,  Yutao Yang,  Chuanfu Zhang,  Pinliang Hu,  Wei Kan,  Xianhong Bai,  Xuelin Liu,  Hongbin Song
Affiliations

Affiliation

  • 1 Institute of Disease Control and Prevention, Chinese Academy of Military Medical Sciences, Beijing, People's Republic of China.
PMID: 20812024 DOI: 10.1007/s00018-010-0511-7
Abstract

The pro-oncogene FBI-1, encoded by Zbtb7a, is a transcriptional repressor that belongs to the POK (POZ/BTB and Krüppel) protein family. In this study, we investigated a potential interaction between Androgen Receptor (AR) signaling and FBI-1 and demonstrated that overexpression of FBI-1 inhibited ligand-dependent AR activation. A protein-protein interaction was identified between FBI-1 and AR in a ligand-dependent manner. Furthermore, FBI-1, AR and SMRT formed a ternary complex and FBI-1 enhanced the recruitment of NCoR and SMRT to endogenous PSA upstream sequences. Our data also indicated that the FBI-1-mediated inhibition of AR transcriptional activity is partially dependent on HDAC. Interestingly, FBI-1 plays distinct roles in regulating LNCaP (androgen-dependent) and PC-3 cell (androgen-independent) proliferation.

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