2. Academic Validation
  3. Dihydro-resveratrol--a potent dietary polyphenol

Dihydro-resveratrol--a potent dietary polyphenol

  • Bioorg Med Chem Lett. 2010 Oct 15;20(20):6149-51. doi: 10.1016/j.bmcl.2010.08.002.
Andrei A Gakh 1,  Natalia Yu Anisimova,  Mikhail V Kiselevsky,  Sergey V Sadovnikov,  Ivan N Stankov,  Mikhail V Yudin,  Konstantin A Rufanov,  Mikhail Yu Krasavin,  Andrey V Sosnov
Affiliations

Affiliation

  • 1 Oak Ridge National Laboratory, Oak Ridge, TN 37831-6242, USA. gakhaa@ornl.gov
PMID: 20813524 DOI: 10.1016/j.bmcl.2010.08.002
Abstract

Dihydro-resveratrol (dihydro-R), a prominent polyphenol component of red wine, has a profound proliferative effect on hormone-sensitive tumor cell lines such as breast Cancer cell line MCF7. We found a significant increase in MCF7 tumor cells growth rates in the presence of picomolar concentrations of this compound. The proliferative effect of dihydro-R was not observed in cell lines that do not express hormone receptors (MDA-MB-231, BT-474, and К-562).

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