2. Academic Validation
  3. Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

Structure activity relationship studies of imidazo[1,2-a]pyrazine derivatives against cancer cell lines

  • Eur J Med Chem. 2010 Nov;45(11):5208-16. doi: 10.1016/j.ejmech.2010.08.035.
Shailaja Myadaraboina 1,  Manjula Alla,  Venkateshwarlu Saddanapu,  Vittal Rao Bommena,  Anthony Addlagatta
Affiliations

Affiliation

  • 1 Organic Chemistry Division-II, Indian Institute of Chemical Technology, Tarnaka-uppal road, Tarnaka, Hyderabad 500607, India.
PMID: 20832916 DOI: 10.1016/j.ejmech.2010.08.035
Abstract

Designed novel imidazo[1,2-a]pyrazine based inhibitors, synthesized by condensing α-aminopyrazines with α-halocarbonyl compounds followed by electrophilic substitutions. Cytotoxic effects on four Cancer cell lines evaluated. Based on preliminary data, imidazo[1,2-a]pyrazine template redesigned to improve activity.

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