2. Academic Validation
  3. Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition

Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition

  • Eur J Med Chem. 2010 Nov;45(11):5044-50. doi: 10.1016/j.ejmech.2010.08.012.
Jyothi Vantikommu 1,  Sadanandam Palle,  Punganuru Surendra Reddy,  Vinodkumar Ramanatham,  Mukkanti Khagga,  Venkateswara Rao Pallapothula
Affiliations

Affiliation

  • 1 Department of Chemistry, Nizam College, Osmania University, Hyderabad 500006, Andhra Pradesh, India.
PMID: 20833451 DOI: 10.1016/j.ejmech.2010.08.012
Abstract

A facile and highly efficient method for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles (β-keto 1,2,3-triazoles) in good to excellent yields from in-situ generated β-ketoazides and terminal alkynes through Cu(I) catalyzed 1,3 dipolar cycloaddition is described. This reaction proceeds smoothly either in water or in a 1:1 mixture of water and acetone at room temperature without use of any additive. The synthesized compounds were screened for their cytotoxicity in A549 (Lung Cancer), HT-29 (Colon Cancer), He La (Cervical Cancer) using MTT assay that exhibited significant cytotoxicity at modest doses.

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