2. Academic Validation
  3. Synthesis and biological evaluation of indolyl glyoxylamides as a new class of antileishmanial agents

Synthesis and biological evaluation of indolyl glyoxylamides as a new class of antileishmanial agents

  • Bioorg Med Chem Lett. 2010 Nov 1;20(21):6191-4. doi: 10.1016/j.bmcl.2010.08.119.
Shikha S Chauhan 1,  Leena Gupta,  Monika Mittal,  Preeti Vishwakarma,  Suman Gupta,  Prem M S Chauhan
Affiliations

Affiliation

  • 1 Division of Medicinal and Process Chemistry, Central Drug Research Institute, CSIR, Lucknow 226001, India.
PMID: 20850302 DOI: 10.1016/j.bmcl.2010.08.119
Abstract

A series of indolylglyoxylamide derivatives have been synthesized and evaluated in vitro against amastigote form of Leishmania donovani. Compound 8c has been identified as the most active analog of the series with IC(50) value of 5.17μM and SI value of 31.48, and is several folds more potent than the standard drugs sodium stilbogluconate and pentamidine.

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