Structure and cytotoxicity of diterpenoids from Isodon eriocalyx

J Nat Prod. 2010 Nov 29;73(11):1803-9. doi: 10.1021/np1004328.

Xiao-Nian Li ¹, Jian-Xin Pu, Xue Du, Li-Guang Lou, Li-Mei Li, Sheng-Xiong Huang, Bo Zhao, Mei Zhang, Fei He, Xiao Luo, Wei-Lie Xiao, Han-Dong Sun

Affiliations

Affiliation

1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.

PMID: 20949916 DOI: 10.1021/np1004328

Abstract

A new ent-atisanoid, eriocatisin A (1), six new ent-abietanoids, eriocasins B-E (2-4, 7), 3-acetyleriocasin C (5), and 3β-acetoxyeriocasin D (6), and seven new ent-kauranoids, maoesins A-F (8, 10-14) and 3α-acetoxy-maoesin A (9), together with 21 known compounds, were isolated from the aerial parts of Isodon eriocalyx. The structures of 1-14 were determined by spectroscopic data interpretation. All compounds isolated were evaluated for their in vitro growth inhibitory activity against the HT-29, BEL-7402, and SK-OV-3 human Cancer cell lines. Compounds 17, 18, and 20 showed inhibitory effects for all three tumor cell lines used, with IC(50) values in the range 2.1-7.3 μM.

Name
Email *

	Sorry, but the email address you supplied was invalid.