Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus

J Nat Prod. 2010 Nov 29;73(11):1756-62. doi: 10.1021/np1002143.

Shwu-Jen Wu ¹, Yann-Lii Leu, Chou-Hsiung Chen, Chih-Hua Chao, De-Yang Shen, Hsiu-Hui Chan, E-Jian Lee, Tian-Shung Wu, Yea-Hwey Wang, Yuh-Chiang Shen, Keduo Qian, Kenneth F Bastow, Kuo-Hsiung Lee

Affiliations

Affiliation

1 Department of Medical Technology, Chung Hua University of Medical Technology, Tainan 717, Taiwan, Republic of China.

PMID: 21028898 DOI: 10.1021/np1002143

Abstract

Ten new triterpenoids, camphoratins A-J (1-10), along with 12 known compounds were isolated from the fruiting body of Taiwanofungus camphoratus. Their structures were established by spectroscopic analysis and chemical methods. Compound 10 is the first example of a naturally occurring ergosteroid with an unusual cis-C/D ring junction. Compounds 2-6 and 11 showed moderate to potent cytotoxicity, with EC(50) values ranging from 0.3 to 3 μM against KB and KB-VIN human Cancer cell lines. Compounds 6, 10, 11, 14-16, 18, and 21 exhibited anti-inflammatory NO-production inhibition activity with IC(50) values of less than 5 μM, and were more potent than the nonspecific NOS inhibitor N(ω)-nitro-L-arginine methyl ester.

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