2. Academic Validation
  3. N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells

N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells

  • Bioorg Med Chem Lett. 2010 Dec 15;20(24):7540-3. doi: 10.1016/j.bmcl.2010.09.065.
Yunxue Zhao 1,  Wenjia Liu,  Ying Zhou,  Xiumei Zhang,  Paul V Murphy
Affiliations

Affiliation

  • 1 Department of Pharmacology, School of Medicine, Shandong University, Jinan, PR China. zhaoyunxue@sdu.edu.cn
PMID: 21036045 DOI: 10.1016/j.bmcl.2010.09.065
Abstract

Previously N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin 1 has been shown to display properties associated with inhibition of angiogenesis. Here we examined the anti-tumourigenic role of 1 in a lung Cancer cell line. This agent altered cell surface oligosaccharide expression and inhibited the growth of A549 cells by inducing G1 phase cell cycle arrest and Apoptosis. Furthermore, stress fibre assembly and cell migration in A549 cells was markedly suppressed by 1.

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