2. Academic Validation
  3. Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

Eponemycin, a new antibiotic active against B16 melanoma. I. Production, isolation, structure and biological activity

  • J Antibiot (Tokyo). 1990 Jan;43(1):8-18. doi: 10.7164/antibiotics.43.8.
K Sugawara 1,  M Hatori,  Y Nishiyama,  K Tomita,  H Kamei,  M Konishi,  T Oki
Affiliations

Affiliation

  • 1 Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
PMID: 2106503 DOI: 10.7164/antibiotics.43.8
Abstract

Streptomyces hygroscopicus No. P247-71(ATCC 53709)produced a novel Antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1,2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L- serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor Antibiotics.

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