2. Academic Validation
  3. Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents

Synthesis and in vitro evaluation of novel coumarin-chalcone hybrids as potential anticancer agents

  • Bioorg Med Chem Lett. 2010 Dec 15;20(24):7205-11. doi: 10.1016/j.bmcl.2010.10.116.
Koneni V Sashidhara 1,  Abdhesh Kumar,  Manoj Kumar,  Jayanta Sarkar,  Sudhir Sinha
Affiliations

Affiliation

  • 1 Medicinal and Process Chemistry Division, Central Drug Research Institute, (CDRI-CSIR), Lucknow, India. sashidhar123@gmail.com
PMID: 21071221 DOI: 10.1016/j.bmcl.2010.10.116
Abstract

A series of coumarin-chalcone hybrids have been synthesized and evaluated for their in vitro cytotoxicity against a panel of four human Cancer cell lines and normal fibroblasts (NIH3T3). Among 21 compounds screened, three compounds (23, 25 and 26) showed IC(50) range from 3.59 to 8.12 μM. The most promising compound 26 showed around 30-fold more selectivity towards C33A (cervical carcinoma) cells over normal fibroblast NIH3T3 cells with an IC(50) value of 3.59 μM.

Figures