2. Academic Validation
  3. Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities

Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities

  • Bioorg Med Chem. 2010 Dec 15;18(24):8493-500. doi: 10.1016/j.bmc.2010.10.042.
Ahmed Kamal 1,  B Ashwini Kumar,  Paidakula Suresh,  Satyam Kumar Agrawal,  Gousia Chashoo,  Shashank K Singh,  A K Saxena
Affiliations

Affiliation

  • 1 Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India. ahmedkamal@iict.res.in
PMID: 21074444 DOI: 10.1016/j.bmc.2010.10.042
Abstract

A new class of 4β-N-polyaromatic substituted podophyllotoxin congeners have been synthesized and evaluated for their DNA topoisomerase-II (topo-II) inhibition as well as Anticancer potential in some human Cancer cell lines. The ease of synthesis and interesting biological activities make the present series of polyaromatic-podophyllotoxin congeners as a promising new structure for the development of new Anticancer agents based on podophyllotoxin scaffold.

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