2. Academic Validation
  3. Pyridone and tetramic acid alkaloids from the spider pathogenic fungus Torrubiella sp. BCC 2165

Pyridone and tetramic acid alkaloids from the spider pathogenic fungus Torrubiella sp. BCC 2165

  • J Nat Prod. 2010 Dec 27;73(12):2057-60. doi: 10.1021/np100492j.
Masahiko Isaka 1,  Panida Chinthanom,  Sumalee Supothina,  Punsa Tobwor,  Nigel L Hywel-Jones
Affiliations

Affiliation

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani, Thailand. isaka@biotec.or.th
PMID: 21090800 DOI: 10.1021/np100492j
Abstract

Torrubiellones A-D (1-4), new pyridone and tetramic acid Alkaloids, were isolated from the spider pathogenic fungus Torrubiella sp. BCC 2165. Torrubiellone A (1) exhibited antimalarial activity with an IC(50) value of 8.1 μM, while it showed very weak cytotoxic activity.

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