2. Academic Validation
  3. Discovery of highly potent agents against influenza A virus

Discovery of highly potent agents against influenza A virus

  • Eur J Med Chem. 2011 Jan;46(1):52-7. doi: 10.1016/j.ejmech.2010.10.010.
Xin Zhao 1,  Chufang Li,  Shaogao Zeng,  Wenhui Hu
Affiliations

Affiliation

  • 1 Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, 190 Kai Yuan Avenue, Guangzhou Science Park, Guangzhou 510530, People's Republic of China.
PMID: 21094565 DOI: 10.1016/j.ejmech.2010.10.010
Abstract

We previously reported several new M2 inhibitors as active as amantadine against influenza A virus and validated by three types of in vitro assays. Herein, we further modified one of the most potent hits in a viral inhibition assay and conducted structure-activity relationship studies on this scaffold. As a result, compound 8e was identified to be the most potent inhibitor against wild-type influenza A virus, being nearly 240-fold more active than amantadine.

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