2. Academic Validation
  3. Glycosylated nordihydroguaiaretic acids as anti-cancer agents

Glycosylated nordihydroguaiaretic acids as anti-cancer agents

  • Bioorg Med Chem Lett. 2011 Jan 1;21(1):380-2. doi: 10.1016/j.bmcl.2010.10.137.
Jih Ru Hwu 1,  Chuan-I Hsu,  Ming-Hua Hsu,  Yu-Chuan Liang,  Ru Chih C Huang,  Yuan C Lee
Affiliations

Affiliation

  • 1 Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC. jrhwu@mx.nthu.edu.tw
PMID: 21123067 DOI: 10.1016/j.bmcl.2010.10.137
Abstract

Three perglycosylated nordihydroguaiaretic acids (NDGA) were synthesized through the Huiseng 1,3-dipolar cycloaddition reaction. These sugar-NDGA conjugates containing triazole-linkages possessed good solubility in water. NDGA-(triazol-galactose)(4) (12b) and NDGA-(triazol-glucose)(4) (12c) were found to act as inhibitors against human hepatocellular carcinoma Hep3B cells in culture.

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