2. Academic Validation
  3. Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

Synthesis and SAR study of diphenylbutylpiperidines as cell autophagy inducers

  • Bioorg Med Chem Lett. 2011 Jan 1;21(1):234-9. doi: 10.1016/j.bmcl.2010.11.029.
Gang Chen 1,  Hongguang Xia,  Yu Cai,  Dawei Ma,  Junying Yuan,  Chengye Yuan
Affiliations

Affiliation

  • 1 State Key Laboratory of Bio-organic and Natural Product Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
PMID: 21126871 DOI: 10.1016/j.bmcl.2010.11.029
Abstract

A novel series of diphenylbutylpiperidines as Autophagy inducers was described and extensive SAR studies resulted in derivatives (15d-e, 15i-j) with 10-fold greater activity than the lead compounds 1 and 2. Meanwhile, a new synthetic route to diphenylbutyl bromide (6) from bromobenzene and γ-butyrolactone was also reported here.

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