2. Academic Validation
  3. Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma

Cytotoxic and protective DNA damage of three new diterpenoids from the brown alga Dictoyota dichotoma

  • Eur J Med Chem. 2011 Jan;46(1):175-82. doi: 10.1016/j.ejmech.2010.10.033.
Seif-Eldin N Ayyad 1,  Mohamed S Makki,  Nazeeha S Al-Kayal,  Salim A Basaif,  Kalid O El-Foty,  Abdullah M Asiri,  Walied M Alarif,  Farid A Badria
Affiliations

Affiliation

  • 1 Department of Chemistry, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia. snayyad2@yahoo.com
PMID: 21130542 DOI: 10.1016/j.ejmech.2010.10.033
Abstract

Three new diterpenes Amijiol acetate (3), dolabellane, Dolabellatrienol (4), and dolastane, Amijiol-7, 10-diacetate (9) were isolated together with the previously described Pachydictyol A (1), Isopachydictyol A (2), 8β-hydroxypachydictyol A (5), Amijiol (6), Isodictyohemiacetal (7) and Dictyol C (8) from the Red Sea brown alga Dictyota dichotoma var. implexa. The structures and relative stereochemistry of the new Diterpenoids were proposed on the basis of their spectral data. Compounds 3 and 9 have potent activity against DNA damage, cytotoxicity against WI-38, HepG2, and MCF-7 cell lines, and antioxidant using ABTS and erythrocytes hemolysis.

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