2. Academic Validation
  3. A helix-loop-helix protein related to the immunoglobulin E box-binding proteins

A helix-loop-helix protein related to the immunoglobulin E box-binding proteins

  • Mol Cell Biol. 1990 Aug;10(8):4384-8. doi: 10.1128/mcb.10.8.4384-4388.1990.
C S Carr 1,  P A Sharp
Affiliations

Affiliation

  • 1 Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
PMID: 2115126 DOI: 10.1128/mcb.10.8.4384-4388.1990
Abstract

A human cDNA encoding a novel protein in the helix-loop-helix family has been isolated by screening a bacteriophage expression library with a probe containing the binding site for major late transcription factor. The protein encoded by this cDNA, TFEB, probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.

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