2. Academic Validation
  3. Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease

Alkaloids from stems of Esenbeckia leiocarpa Engl. (Rutaceae) as potential treatment for Alzheimer disease

  • Molecules. 2010 Dec 13;15(12):9205-13. doi: 10.3390/molecules15129205.
Elaine Monteiro Cardoso-Lopes 1,  James Andreas Maier,  Marcelo Rogério da Silva,  Luis Octávio Regasini,  Simone Yasue Simote,  Norberto Peporine Lopes,  José Rubens Pirani,  Vanderlan da Silva Bolzani,  Maria Cláudia Marx Young
Affiliations

Affiliation

  • 1 Section of Plant Physiology and Biochemistry, Institute of Botany, Box 3005, 01061-970 São Paulo, SP, Brazil.
PMID: 21160449 DOI: 10.3390/molecules15129205
Abstract

Esenbeckia leiocarpa Engl. (Rutaceae), popularly known as guarantã, goiabeira, is a native tree from Brazil. Bioactivity-guided fractionation of the ethanol stems extract afforded the isolation of six alkaloids: leiokinine A, leptomerine, kokusaginine, skimmianine, maculine and flindersiamine. All isolated compounds were tested for acetyl cholinesterase inhibition, in vitro and displayed anticholinesterasic activity. The alkaloid leptomerine showed the highest activity (IC₅₀ = 2.5 mM), similar to that of the reference compound galanthamine (IC₅₀ = 1.7 mM). The results showed for the first time the presence of Alkaloids leptomerine and skimmianine in E. leiocarpa (Engl.) with potent anticholinesterasic activity.

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