2. Academic Validation
  3. Listericidal activity of human neutrophil cathepsin G

Listericidal activity of human neutrophil cathepsin G

  • J Gen Microbiol. 1990 Jun;136(6):997-100. doi: 10.1099/00221287-136-6-997.
C E Alford 1,  E Amaral,  P A Campbell
Affiliations

Affiliation

  • 1 Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206.
PMID: 2117044 DOI: 10.1099/00221287-136-6-997
Abstract

We demonstrate that Cathepsin G, derived from human neutrophils, exhibits potent in vitro antimicrobial activity against Listeria monocytogenes. Cathepsin G listericidal activity was by a non-enzymic mechanism and was dependent on the cationic nature of the molecule. The listericidal activity of Cathepsin G occurred in a manner that was both time-dependent and concentration-dependent.

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