Pyrrolidinone diterpenoid from Isodon excisus and inhibition of nitric oxide production in lipopolysaccharide-induced macrophage RAW264.7 cells

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1279-81. doi: 10.1016/j.bmcl.2010.11.095.

Seong Su Hong ¹, Seon A Lee, Nahyun Kim, Ji Sang Hwang, Xiang Hua Han, Mi Kyeong Lee, Jae Kyung Jung, Jin Tae Hong, Youngsoo Kim, Dongho Lee, Bang Yeon Hwang

Affiliations

Affiliation

1 College of Pharmacy, Chungbuk National University, Cheongju, Chungbuk 361-763, Republic of Korea.

PMID: 21273070 DOI: 10.1016/j.bmcl.2010.11.095

Abstract

A new pyrrolidinone diterpenoid, excisusin F (1), was isolated from the aerial parts of Isodon excisus (Lamiaceae), together with four known compounds, and their structures were determined mainly by NMR (1D and 2D) and mass spectrometry. Excisusin F (1) and inflexarabdonin E (3) showed potent inhibitory effects of LPS-induced nitric oxide production in RAW264.7 cells with the IC(50) value of 10.4 and 3.8 μM, respectively.

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