Cytotoxic pentacyclic and tetracyclic aromatic sesquiterpenes from Phomopsis archeri

J Nat Prod. 2011 Apr 25;74(4):609-13. doi: 10.1021/np100632g.

Chulida Hemtasin ¹, Somdej Kanokmedhakul, Kwanjai Kanokmedhakul, Chariya Hahnvajanawong, Kasem Soytong, Samran Prabpai, Palangpon Kongsaeree

Affiliations

Affiliation

1 Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

PMID: 21341709 DOI: 10.1021/np100632g

Abstract

Three new Sesquiterpenes, named phomoarcherins A-C (1-3), and four known compounds, kampanol A (4), R-mevalonolactone, ergosterol, and ergosterol peroxide, were isolated from the endophytic fungus Phomopsis archeri. These structures were established on the basis of spectroscopic evidence. The structure and absolute configuration of 1 were confirmed by X-ray crystallographic analysis of its p-bromobenzoate derivative (1a). Compounds 1-4 showed cytotoxicity against five cholangiocarcinoma cell lines (0.1-19.6 μg/mL), while 1 and 2 exhibited weak cytotoxicity against the KB cell line with IC(50) values of 42.1 and 9.4 μg/mL, respectively. In addition, compound 2 showed antimalarial activity against Plasmodium falciparum with an IC(50) value of 0.79 μg/mL.

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