2. Academic Validation
  3. Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

Isatin-β-thiosemicarbazones as potent herpes simplex virus inhibitors

  • Bioorg Med Chem Lett. 2011 Apr 1;21(7):1948-52. doi: 10.1016/j.bmcl.2011.02.037.
Iou-Jiun Kang 1,  Li-Wen Wang,  Tsu-An Hsu,  Andrew Yueh,  Chung-Chi Lee,  Yen-Chun Lee,  Ching-Yin Lee,  Yu-Sheng Chao,  Shin-Ru Shih,  Jyh-Haur Chern
Affiliations

Affiliation

  • 1 Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County 350, Taiwan, ROC.
PMID: 21356589 DOI: 10.1016/j.bmcl.2011.02.037
Abstract

A series of isatin-β-thiosemicarbazones have been designed and evaluated for Antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay. Their cytotoxicity was examined using human rhabdomyosarcoma cells (RD cells). Several derivatives of isatin-β-thiosemicarbazone exhibited significant and selective Antiviral activity with low cytotoxicity. It was found that the thiourea group at thiosemicarbazone and the NH functionality at isatin were essential for their antiherpetic activity. The synthesis and structure-activity relationship studies are presented.

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