2. Academic Validation
  3. Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

Discovery of indole alkaloids with cannabinoid CB1 receptor antagonistic activity

  • Bioorg Med Chem Lett. 2011 Apr 1;21(7):1962-4. doi: 10.1016/j.bmcl.2011.02.036.
Mariko Kitajima 1,  Masumi Iwai,  Ruri Kikura-Hanajiri,  Yukihiro Goda,  Mitsuru Iida,  Hisatoshi Yabushita,  Hiromitsu Takayama
Affiliations

Affiliation

  • 1 Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
PMID: 21376588 DOI: 10.1016/j.bmcl.2011.02.036
Abstract

Three Indole Alkaloids, voacamine (1), 3,6-oxidovoacangine (2), and a new alkaloid, 5-hydroxy-3,6-oxidovoacangine (3), isolated from Voacanga africana were found to exhibit potent cannabinoid CB1 receptor antagonistic activity. This is the first example of CB1 antagonists derived from natural Alkaloids.

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